What are PDE5 Inhibitors?
PDE5 inhibitors are the class of medications that are used to treat erectile dysfunction. Initially, Phosphodiesterase 5 inhibitors were discovered for treating high blood pressure and angina. However, for treating erectile dysfunction, it was discovered accidentally by a trusted source Pfizer. It is believed to be one of the most satisfactory medicine for curing sexual dysfunction in men of every age. It is approximated that more than 60 million meals in the world are dealing with sexual disorders. Older men earlier faced this problem but nowadays with changing lifestyles, it started showing symptoms in younger men too. PDE5 inhibitors are often used to treat people with symptoms of erectile dysfunction generally caused by a lack of blood flow into the penis.
How do PDE5 Inhibitors work?
PDE5 inhibitors have a direct effect on the penis, which helps the blood vessels to relax. It improves the blood flow in the region, which allows for erection.
The procedure of erection is very complex. When you are sexually active, the nervous system surrounding the penis region becomes aroused. This action leads to a release of a kind of molecule named nitric oxide (NO). The undefined amount of nitric oxide improves the exposition of another molecule named cyclic GMP. This molecule assists in relaxing the muscle in the blood vessel and raises the flow of blood in the penis region by 40 times.
PDE5 Inhibitors assist in breaking down cyclic GMP molecules and inverting the process of erection. They are similar to the structure of cyclic GMP, which blocks Phosphodiesterase 5 inhibitors from this breakdown. This process enhances the action of nitric oxide, which supports blood flow in the penis region.
Phosphodiesterase 5 Inhibitors side effects
Some of the common side effects are
- Problem in eyesight
- Back pain
- Muscle pain
Types of PDE5 Inhibitors
There are four significant types of Phosphodiesterase 5 inhibitors
Sildenafil Citrate is the first extensively used PDE5 inhibitor that was approved by the FDA in the year 1998 under the name Viagra. It is recommended by clinicians to treat erectile dysfunction in men. It usually takes 1 hour to show its action on the body. Viagra effects last about 4 hours. The dosage is typically taken between 25 mg to 100 mg a day.
Tadalafil was launched in the market in the year 2003 to treat erectile dysfunction. It usually takes 20 minutes to show its action. It should be swallowed half an hour before sexual interaction. FDA to treat Benign Prostate Hyperplasia (BPH) also approves that laughing. Tadalafil is the longest action available in PDF5 innovators. It lasts up to 24 to 36 hours. Tadalafil dosage varies from 2.5 to 20 mg a day.
Vardenafil was also approved in 2003 for operating erectile dysfunction. It has the quickest onset of any Phosphodiesterase 5 inhibitors which started showing its result within 10 minutes. Verdenafil usually lasts up to 6 to 8 hours. A dose of vardenafil PDE-5 inhibitors is 5 to 20MG per day.
Avanafil is the newest PDE5 inhibitor that started its journey from the year 2012. It takes 30 to 45 minutes to show its effect on the body. Avanafil has a longer duration than Sildenafil or Vardenafil. It lasts around five hours. You can take a dose of 50 to 200 mg in 24 hours.
Phosphodiesterase 5 Inhibitors for erectile dysfunction
PDE5 inhibitors are a type of medication usually use in treating erectile dysfunction in men. This medication is especially effective in ED that is cause by physical disorders like the poor circulation of blood in the penis region. However, they are not effective in treating erectile dysfunction caused by physical factors like stress on anxiety.